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The AOD9604 results were most pronounced in subjects with higher baseline body fat percentages, suggesting greater efficacy in those with more fat to lose
These inflammatory processes or the pro-inflammatory cytokines cause transcriptional, post-transcriptional, and epigenetic changes in the expression of the metabolizing enzymes as well as transport proteins of the liver, and, thereby, influence the plasma level, bioavailability and, thus, efficacy of some drugs [18,20]
