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Rodent studies show they are causally linked, suggesting the presence of biological pathways mediating this link

After metabolic activation, benzo[a]pyrene produces reactive intermediates that form DNA adducts, leading to damage that can result in gene mutations and initiate cancer development (Moore et al., 1982

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Human TFF2-Fc fusion protein alleviates DSS-induced ulcerative colitis in C57BL/6 mice by promoting intestinal epithelial cells repair and inhibiting macrophage inflammation