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methitrexate plus glutathione Methotrexate: Integrating molecular pharmacology, systems toxicology, and precision rescue strategies Full article: The Protective Effect
Description
Studies in animal models with gut microbiota depletion have shown increased plasma tryptophan, elevated brain serotonin concentrations, and reduced kynurenine pathway activity, all of which normalize following microbiota restoration (229231)

Bibcode:2000Sci...289.1567M

In essence, the interplay between MG and the glyoxalase system unfolds as a critical player in the complex landscape of metabolic syndrome-related diseases

D.MurgasC
