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Melatonin improved memory in mice in an AD model by increasing BDNF and CREB1 gene expression in the mouse prefrontal cortex [101]

GRB2 is a BECN1 interacting protein that regulates autophagy

2025 Aug;21(6):1822-1834

[PubMed] Compound 4: TB-500 Research Findings Cellular G-actin sequestration, cytoskeletal remodeling, keratinocyte and endothelial cell migration in Boyden chamber and scratch-wound assays Molecular Integrin-linked kinase (ILK) signaling, PINCH protein interactions, NF-B pathway modulation, MMP-2/MMP-9 expression in cultured fibroblasts and keratinocytes Systemic (Preclinical) Rodent models of dermal wound repair (normal, aged, and db/db diabetic), corneal injury, and cardiac ischemia-reperfusion using full-length TB4 with parallel fragment studies References (TB-500): Malinda KM, et al