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For instance, opioids are linked to respiratory depression, nausea, and vomiting [70], whereas ketamine can cause tachycardia, elevated blood pressure, and psycho-neurological effects such as hallucinations and disorientation [71]

The prolonged contact time with the ocular surface enhances therapeutic efficacy, minimizes drug elimination through tears, and reduces administration frequency

240 The protein has also attracted interest in neurodegenerative conditions, e.g., owing to its elevated concentration in AD brains, accumulation in amyloid plaques and a range of other aggregates or inclusion bodies, and potentially neurotoxic contributions in complex with the A peptide

Hair is the main route by which mercury is excreted in the human body by TTFD [] Considering that the side chains of TPD, TTFD, TATD, etc., change the originally water-soluble substance B into a fat-soluble substance, metals in the body that bind to these side chains become fat-soluble substances, and are likely to be excreted in body hair rather than in urine or feces