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Mutagenicity represents an established surrogate parameter for prediction of the carcinogenic potential, and bacteria-based mutagenicity testing has demonstrated a reasonably good correlation with carcinogenicity, especially for NAs (Bercu et al
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Besides, NOX4 has been specifically linked to oncogenic H-Ras- (H-RasV12-) induced DNA damage and senescence, suggesting a potential role in HCV-related oncogenesis (111)
