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While excessive levels of ROS can cause apoptosis in cancer cells, moderate ROS levels promote tumor development and progression (49)

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

(2025) demonstrated in an intracerebral hemorrhage (ICH) model in mice that HO-1 activates microglia in the later stages of ICH, promotes phagocytosis, enhances the absorption of hematomas and cellular debris, induces neurogenesis and angiogenesis, and thus facilitates brain tissue recovery while attenuating secondary brain injury

Funding Open access funding provided by The Ministry of Higher Education Malaysia and Universiti Putra Malaysia