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However, efficient and targeted intra-articular gene delivery remains a considerable technical challenge, primarily due to the dense extracellular matrix (ECM) of cartilage, rapid clearance of joint fluid, and limited cellular uptake

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These worms were cultured at 20 C for a 24-h fasting period

Moreover, the authors also noted significant improvements in behavior and dopaminergic functions in PD rats, suggesting that intranasal delivery of OE-MSCs may be a promising and minimally invasive alternative in PD treatment [104]