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selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation [2,8,9]
Methylcobalamin and adenosylcobalamin are native forms of B12, while hydroxycobalamin or cyanocobalamin are not
When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair
