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In 2009, alcohol abuse claimed 2.3 million lives internationally (Mokdad et al., 2004)
[DOI] [PubMed] [Google Scholar] Bentley AR, Emrani P, Cassano PA
252,253,254 Nearly 60 cytokines including various interleukins, growth factors and colony-stimulating factors (CSFs) act as ligand to activate this pathway
Therefore, promoting the apoptosis of senescent endothelial cells and improving the microenvironment of aged blood vessels is crucial for maintaining vascular function
