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Histological analysis showed that FOXO4-DRI treatment improved the testicular microenvironment, leading to thicker seminiferous epithelia, increased spermatogenic cells, and more mature spermatozoa in the central lumen
Core nucleoid components such as TFAM, mitochondrial single-stranded DNA-binding protein (mtSSB), DNA polymerase gamma POLG, mitochondrial DNA-dependent RNA polymerase POLRMT, and Lon protease are essential for mtDNA packaging, maintenance, and transcription (Fig
