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Oxidative Stress and Amyotrophic Lateral Sclerosis Presence of OS biomarkers and high levels of ROS have been determined in the CNS regions specifically in ALS patients (Golenia et al., 2014), which indicates that impaired redox homeostasis is a relevant factor and associated with the development and progression of neurodegeneration in fALS and sALS (Carr et al., 2015

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Possibly, the ability of estradiol to upregulate GPx-1 transcription may contribute to the increased expression of GPx-1 in females compared to males (43, 294)

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