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However, recurrent bouts of such inflammation and the toxic milieu that ensues, are thought to produce cumulative damage to myelin, oligodendrocytes and neurons, leading to progressive degeneration, atrophy and increasing disability, exacerbated by failure of myelin repair

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This article examines the historical evolution of medication-assisted treatment (MAT), explores current options, breaks down barriers to access and compliance, and previews promising new pharmacotherapies that could redefine addiction treatment in the years ahead