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Prescription binders like Cholestyramine can cause severe gastrointestinal irritation and are often contraindicated in patients with biliary obstruction

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Wang L, Sparacino-Watkins CE, Wang J, Wajih N, Varano P, Xu QZ, et al

Most patients report only mild discomfort due to the numbing cream applied before the procedure

Similarly, TNF- plus IFN- increment the expression of Cx43 and Panx1 in EOC20 microglial cells in conjunction with the activation of hemichannels and pannexons (Sez et al., 2013)
