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The contribution of oxidative stress to necroptosis appears to be highly context-dependent

The authors found that nuclear factor erythroid-2-related factor 2 (NRF2) as a main transcription factor in response to oxidative stress was significantly induced and bound to the promoter of NPC1L1, therefore transcriptionally contributing to NPC1L1 expression

Journal of Hepatology, 62 (1 Suppl), S47S64
