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doi: 10.1016/S1097-2765(04)00094-2

These were serious enough to interfere with daily functions and turn gym activity into hell
This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake

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