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Various experimental evidences also suggested that the high concentration of cholesterol can arouse breast cancer, hepatocellular carcinoma, etc., due to the declined membrane fluidity 54,55 Experimental evidences have confirmed that the lipid rafts, comprising abundant cholesterol, often mediate the entry of nanomaterials (including GQDs) into cellular membrane 43,56,57 Therefore, in this study, we specifically investigate the interaction between graphene quantum dots (GQDs) and the realistic placental cell membrane, taking into consideration of the plentiful presence of cholesterol in the membrane model

Unfortunately, this process is intimately linked with a poor prognosis

These findings support a model in which XPO-1 binding to the N-terminus of NHR-49 serves as a critical upstream event that promotes NHR-49s association with the nuclear pore complex, potentially coordinating its nuclear engagement under conditions of stress