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Description
the products of these two genes negatively regulate the transcription of the progenitor heterodimer

People with more melanin have darker skin, while those with less have lighter skin

This includes increased phosphorylation of dynamin-related protein 1 (DRP1) at serine-616, promoting mitochondrial fragmentation, and decreased expression of fusion proteins such as mitofusins (MFN1/2) and optic atrophy 1 (OPA1) (Vaccaro et al., 2020
Shiraishi, I
