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This genomic flexibility, coupled with specific mutations in drug targets, overexpression of efflux transporters, and alterations in sterol biosynthesis pathways, enables Leishmania to withstand various therapeutic interventions and develop resistance to multiple drugs

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[DOI] [PubMed] [Google Scholar] 203.Garcia-Jimenez A, Teruel-Puche JA, Berna J, et al

Considering the high plasticity of microglia according to different pathologic events or microenvironments [33], deeper insight into the regulatory mechanisms of microglial phenotype variations may help maintain the homeostasis of microglia activation