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EB, a DNA-alkylating agent, kills astrocytes and oligodendrocytes while sparing axons 139,140 , whereas LPC disrupts oligodendrocyte membranes via detergent-like effects 141,142
Human detrusor smooth muscle cells release interleukin-6, interleukin-8, and RANTES in response to proinflammatory cytokines interleukin-1 and tumor necrosis factor-
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It usually involves difficult or irregular bowel movements, accompanied by hard, dry motions which can be painful to pass
