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Further, excessive Hcy can be converted to a Hcy thiolactone that can react with the -amino group of a protein lysine residue (N - homocysteinylation) and contribute to the manifestations of HHcy [31]

Overcoming the drug resistance of MET-TKIs and ICIs, as well as their toxic and side effects that may affect the drug efficacy, remains a critical challenge

doi: 10.3389/fpls.2022.1040532 166 SlotM.GarciaM
