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This range approaches the levels of surgical anesthesia and can suppress vital life-supporting reflexes, leading to a loss of consciousness and, without immediate medical intervention, a severe risk of coma or death

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This should include careful consideration of the population-level consequences from decades of interdiction efforts that have not resulted in any meaningful reduction in the price or availability of drugs in the community over any substantial period and may contribute to increased risk of overdose and its sequelae, including death." "The number of unintentional poisoning deaths increased from 12,186 in 1999 to 20,950 in 2004