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These results support the role of Hcy-induced inflammation in the dysfunction of blood-retinal barriers and bloodbrain barrier and pathogenesis of diabetic retinopathy, age-related macular degeneration, and AD [106]

Furthermore, MGL exerted its protective effects by inhibiting the PI3K/AKT signaling pathway [492] and the arachidonate 5-lipoxygenase (ALOX5)-mediated ferroptosis, inhibiting M1 while promoting M2 macrophages [493]

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

By activating Sxc , NAC enhances the endogenous activation of presynaptic mGlu2 receptors, thereby inhibiting glutamate release from excitatory nerve endings [114]