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Treatment with diiodothyropropionic acid (DITPA), in animal models and humans with inactivation or mutation in the MCT8 gene, results in reduction in serum TSH and serum T 3 , and an improvement in hypermetabolism with weight gain and reduced caloric needs (60, 262)

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Moreover, high-dose L-carnitine supplementation completely prevented the reduction in mitochondrial function markers (Figures 5C, D), and ultimately attenuated cytotoxicity (Figure 5E) in lenvatinib-treated C2C12 myocytes