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Anatomic association (in contiguity) of DN has been observed in 36% of sporadic primary melanomas, in about 70% of familial primary melanomas, and in 94% of melanomas with familial melanoma and DN

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Indeed, optogenetic activation of vlPOA VGAT neurons potently induced hypothermia in Vgat-cre mice, as did chemogenetic silencing of DMH VGAT neurons, both of which induced neuroprotection by inhibiting cerebral reperfusion injury

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2004;20:233-42, v

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