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However, extended clinical trials are still needed to examine its therapeutic potential and functional mechanisms

Similarly, subcutaneous administration of progesterone prevented mechanical and thermal allodynia in male rats following SCI rats, and decreased levels of the pro-inflammatory cytokines IL-1, IL-6, and TNF in the spinal cord dorsal horn, supporting the notion that progesterone has a capability of suppressing reactive gliosis following CNS injury [373]

Chawla, M., Verma, J., Gupta, R

In addition, chronological aging of the skin is influenced by genetics, metabolism, and hormonal, immunological, cardiovascular, gastrointestinal, psychogenic (involving stress or affective disorders), degenerative, or neoplastic disease [16,17,18]