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Although it shows a protective effect against hypertension and kidney damage induced by RUPP rats when administered in late gestation, it exacerbates the preeclampsia-like phenotype when given in early gestation, predisposing to a smaller placenta and increasing proteinuria

However, the conveyance of exogenous cellular material to hepatocytes by macrophages, notably Kupffer cells, presents a formidable technical hurdle [161]

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