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The subsequent TBI exacerbates inflammatory processes, leads to glial activation, and contributes to a reduction in the mtDNA content in the damaged region of the brain
274,275 Therapeutic strategies targeting oxidative stress and mitochondrial dysfunction include using antioxidants like alpha-lipoic acid (ALA), which improves neuropathic symptoms and nerve conduction velocities in patients with DPN
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Under normal conditions, NRF2 is bound to Kelch-like ECH-associated protein 1 (Keap1) in the cytosol
