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CHALLENGES OF THE FIELD While much has been learned about the aging metabolome, there are many challenges to its study, some of which are inherent to contemporary metabolomics methodology

Stretch marks represent a specific type of dermal scarring from rapid skin stretching

The LRRK2 mutations impair synaptic vesicle endocytosis, leading to alterations of DA metabolism and DA-mediated toxic effects in dopaminergic neurons derived from iPSCs generated from reprogrammed PD patient fibroblasts carrying LRRK2 mutations [132]