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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC 50 value (IC 50 = ~1 M;[17]), and high cell membrane permeability (Table 2), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors (Figure 2D)
This intracellular reduction process involves ascorbic acid
Compounded medications do not undergo the same FDA review process as finished FDA-approved drugs
doi: 10.1038/srep01393 180 QureshiSTLarivireLLevequeGClermontSMooreKJGrosPet al
