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These nanomaterials are primarily categorized into two types: first, the internal response systems that respond to intrinsic TME signals (e.g., metabolic disorders, redox balance, specific enzymes, or ions), designed to capitalize on the inherent weaknesses of tumors

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*Correspondence: Haider Raza, [email protected] This article was submitted to Metabolic Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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