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Skin lightening, immune support, and detox protocols each require different session frequencies and durations

Stress management becomes especially important during this phase, as the anxiety about hair loss can elevate cortisol and worsen the problem

It can be seamlessly integrated with other treatments and therapies to enhance their effectiveness

Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)