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There are no useful placebo controlled trials in humans for either

Kolahi, Z., Yaghoubi, A., Rezaeian, N

Abstract Neisseria meningitidis (meningococcus) is a transitory colonizer of the human nasopharynx that occasionally, for largely unknown reasons, reaches the bloodstream, translocating across the nasopharyngeal mucosa, causing septicemia

VEGF overexpression is especially critical, as tumor cells use it to drive angiogenesis around them, securing essential oxygen and nutrients for growth and metastasis [195]
