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Description
The aggresome pathway is particularly important in neurons, which are highly susceptible to the accumulation of misfolded proteins due to their long lifespan and complex structure

In the brain, GLAST (also known as EAAT1) and GLT-1 (also known as EAAT2) are primarily distributed in astrocytes, whereas EAAC1 is exclusively expressed in neurons

Chaneton, B

Direct evidence from multi-omics analyses of airway host-microbe interactions in COPD patients indicated that indole-3-acetic acid (IAA) derived from airway microbiota alleviated neutrophil inflammation, cell apoptosis, emphysema, and lung function decline through IL-22-mediated macrophage-epithelial cell interactions
