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Several studies implementing similar study designs yielded non-significant findings (Wilkerson et al., 2012)

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Lamanna-Rama N, Romero-Miguel D, Desco M, Soto-Montenegro ML (2022) An update on the exploratory use of curcumin in neuropsychiatric disorders

ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways