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To determine the optimal in vivo dose of 48c for our study, based on previously reported doses 33,34,35,36,37 , we treated the mice with 20 or 40 mg/kg 48c and found that although 20 mg/kg 48c efficiently inhibited Tm-induced Xbp1s expression, 40 mg/kg was required to increase Gclc expression level in the kidney (Supplementary Fig

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In this trial, axokine resulted in an average weight loss of 2.9 kg, as compared to an average weight loss of 1.1 kg with placebo

Moreover, the oxidation of surface proteins on the sperm membrane can impair the sperms ability to recognize and bind to the oocyte, further reducing the likelihood of successful fertilization