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First of all, a robust framework for ex vivo manipulation with patients cells should be created, which significantly complicates the therapeutic conditions and increases the final cost of this therapy

Since IC is a chronic condition, therapy and monitoring should be carried out over the long term [19]

FerroDBarattaFPastoriDCocomelloNColantoniAAngelicoFet al

Spatial transcriptomic analyses reveal that DTX3L, an epithelial marker, and BST2, a stromal marker, are co-upregulated in esophageal squamous cell carcinoma, promoting M2 polarization and driving tumorigenesis, however their universality across cancer types remains to be validated (317)