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Chemical conjugation of epothilone with glutathione was studied, displaying a noticeable increasing of its anticancer activity towards various tumor cells [75], however, using several chemicals as cross-linkers for orienting the reaction, and checking the progress of reaction, and extra steps for purifying the conjugate is the major challenge

Glutathione A powerful antioxidant and helps the body process the effects of alcohol

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Thus, the impairment of these systems can lead to longer contact times of formulations, physiologic impairment and damage of the mucosa and the nasal epithelium