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While not confirmed by specific neuronal markers, the selectivity of staining is indicative of neuronal expression, a conclusion confirmed by immunostaining of mouse periventricular neurons 43

[DOI] [PubMed] [Google Scholar] 286.Nimse D.P

When folate is insufficient or in the wrong form (synthetic folic acid), methylation stalls, SAM drops, and COMT function suffersleading to either too-fast clearance (when the system is overwhelmed) or too-slow clearance (when methylation is depleted)
