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The depletion of NADPH results in increased oxidative stress within the cell as it is a required cofactor in the production of GSH, and this oxidative stress can result in DNA damage
Theres very few, if not only one, human trial that was a retrospective study, looking at knee pain, and they injected people with BPC-157
1 , a001651 (2009)
Liver pathology in infantile mitochondrial DNA depletion syndrome
