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Elevated cAMP levels are believed to possibly activate protein kinase A (PKA), a molecule that appears integral to intracellular signaling
The Pontryagins Minimum Principle and Hamiltonian equations are used to derive the optimality conditions

doi: 10.1016/j.ynstr.2015.12.002

29,30,32 It has been proposed that the expression of inflammatory cytokines is increased in painful IVDs
