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3.1.2 Ferroptosis-related lipid metabolism and RCC The acyl-CoA synthetase family member ACLS3 not only regulates the accumulation of lipid droplets in ccRCC and is essential for tumor growth, but also regulates sensitivity to ferroptosis in a manner dependent on the composition of exogenous fatty acids: both functions are implicated in the treatment of ccRCC (83)

Cuando se optimizan los moduladores adecuados, el sistema de antioxidantes celulares puede trabajar de forma ms eficiente, favoreciendo un estado de equilibrio sostenido sin necesidad de intervenir directamente sobre molculas finales

Nature 649 , 477486 (2025)

Natural compounds such as sulforaphane, found in cruciferous vegetables, have gained prominence for their ability to activate the Nrf2-Keap1 pathway, promoting the transcription of genes encoding antioxidant enzymes, such as SOD and CAT, reinforcing the adaptive cellular response to oxidative stress [34, 35]
