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Third, it resists degradation by gamma-glutamyl transpeptidase enzymes
therapy including the treatment of neuropathy and pain resulting from cancer treatments, nerve damage, and diabetes
Unlike the Trx -/- and TrxR -/- mice that are embryonic lethal but the conditional knockouts are well tolerated in vivo [20,106], the complete knock down of Grx3 leads also to cell death in cultures of human and mouse cell lines
These findings suggest that there is an endogenous system for keeping neuroglobin in an active form
