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For instance, POMC neurons in the NTS show the signal transduction activated transcript 3 (STAT3) activation in response to leptin [18]
Such a mechanism could theoretical be mediated by the oncoprotein MDM2, which interacts with p53 but has recently also been found to associate with certain cell surface receptors and regulate their functions (Shenoy et al, 2001)
DOI: 10.1016/j.freeradbiomed.01.012 23
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