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doi: 10.1016/s0022-510x(00)00386-5

The extracellular matrix (ECM) is a network of extracellular macromolecules, enzymes, collagen, and other biomolecules that provide support for surrounding cells

Homocysteine also triggers ROS generation and reduces the generation of nitric oxide (NO) with activation of inflammatory series leading to progressive neuronal loss (Hassin-Baer et al

doi:10.1016/j.freeradbiomed.2013.08.163