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The antigen is a purified truncated form of the glycoprotein, expressed in Chinese hamster ovary cells

Among these, the activation of protein kinases, particularly the Src family kinases, plays a pivotal role in phosphorylating and activating subsequent downstream effectors

This mitochondrial GSH depletion is accompanied by evidence of mitochondrial oxidative stress, including increased levels of 8-OHdG, and significant loss of aconitase activity, a mitochondrial enzyme particularly sensitive to inactivation by superoxide radical (Velsor et al., 2006)

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation