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Description
The outcome included in the meta-analysis was other cancers of the pharynx

nuclear fractions: p AIF@3 h = 0.017, p AIF@6 h = 0.099, p EndoG@3 h = 0.001, p EndoG@6 h = 0.240)

Growth depends on how well it adapts beyond cigarettes

If a person continuously chews tobacco then short-term disease may lead to long-term and causes severe health problems like cancer, lung disease, heart disease, stroke, etc
