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Upregulation of Alternative Angiogenic Pathways The activation of compensatory pro-angiogenic pathways in response to anti-VEGF therapy is a well-established mechanism of acquired resistance in tumors (Ramadan et al., 2020)

For some individuals, vitamin B12 injections may be recommended where deficiency has been identified or absorption is impaired

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[DOI] [PubMed] [Google Scholar] 75.Picksak G., Luft C., Stichtenoth D.O