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Description
Studies have shown that Erastin can reverse the M2 polarization of tumor-associated macrophages (TAMs) and promote their conversion to the M1 phenotype, significantly increasing TNF- secretion to remodel the immunosuppressive microenvironment (222)
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Nature 428 , 486 (2004)
JV, DK, MS, and ABB did the literature search and wrote the initial version of the manuscript
