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treatment and care costs are presently $70-100 billion [12] and worldwide more than $600 billion [13] , a number predicted to reach $3 trillion by 2050 [11]

The treatment difference of 17.3 percentage points versus placebo represents the largest weight reduction achieved by any pharmacotherapy in a Phase 3 trial

Therefore, it is crucial to study the key factors that regulate secondary nerve injury after TBI and identify new targets for improving the prognosis of patients with TBI

12%) achieved weight loss 10% and 50.5% (vs
